INDOLECARBOXAMIDE DERIVATIVE

[Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby c...

Full description

Saved in:
Bibliographic Details
Main Authors TAKATOSHI KANAYAMA, NAOTO KATOH, TOMOYUKI SAITO, SHIGEO MATSUI, HIDEKI KUBOTA, SHUNICHIRO MATSUMOTO, TAKAFUMI SHIMIZU
Format Patent
LanguageEnglish
Portuguese
Published 05.12.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:[Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.
Bibliography:Application Number: PT20130816547T