PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

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Bibliographic Details
Main Authors JIANG ZHU, YOSUP REW, ZHIHONG LI, JOEL MCINTOSH, BRIAN MATTHEW FOX, JONATHAN DANTE LOW, MICHAEL WILLIAM GRIBBLE, JASON DUQUETTE, FÉLIX GONZALEZ LOPEZ DE TURISO, STEVEN HOWARD OLSON, JIWEN LIU, LAWRENCE MCGEE, BENJAMIN FISHER, DAVID JOHNKOPECKY, FRANK KAYSER, JIASHENG FU, DUSTIN MCMINN, JULIO CESAR MEDINA, HILARY PLAKE BECK, JULIE ANNE HEATH, MING YU, XIAOQI CHEN, MICHAEL JOHNSON, ZHIHUA MA, XIN HUANG, YINGCAI WANG, SUJEN LAI, MICHAEL DAVID BARTBERGER, XUELEI YAN, BRIAN STUART LUCAS, JEFFREY DEIGNAN, RICHARD VICTOR CONNORS, JOHN EKSTEROWICZ, DAQING SUN, ANA GONZALEZ BUENROSTRO, YIHONG LI, JEFFREY THOMAS MIHALIC, PHILIP MARLEY ROVETO, ZICE FU
Format Patent
LanguageEnglish
Portuguese
Published 01.07.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Bibliography:Application Number: PT20110726581T