4-(INDOL-7-YLCARBONYLAMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS USEFUL FOR THE TREATMENT OF CHRONIC RENAL FAILURE OR DIABETIC NEPHROPATHY

The present invention relates to amide compounds of formula I which are EP4 receptor antagonists and useful for treating chronic renal failure and/or diabetic nephropathy. Ring D is a group of formula II; V and W are CH; R 45 is -CH 2 -B 5 ; B 5 represents a bicyclic hetero ring which may be substit...

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Main Authors KAZUHIRO IKEGAI, RYUSHI SEO, EISUKE NOZAWA, MICHIHITO KAGEYAMA, TATSUYA ZENKOH, RYOTARO IBUKA, KEISUKE MATSUURA, SUSUMU WATANUKI
Format Patent
LanguageEnglish
Portuguese
Published 04.12.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to amide compounds of formula I which are EP4 receptor antagonists and useful for treating chronic renal failure and/or diabetic nephropathy. Ring D is a group of formula II; V and W are CH; R 45 is -CH 2 -B 5 ; B 5 represents a bicyclic hetero ring which may be substituted with one or more groups selected from the group consisting of halogen and C 1-6 alkyl; R 46 is H, halogen, C 1-6 alkyl which may be substituted with one or more halogens, or -O-C 1-6 alkyl; -NR 1 -YR 2 - is -NH-CH 2 -; Ring E is cyclohexane-1,4-diyl; and -Z-R 3 is -CO 2 H.
Bibliography:Application Number: PT20120194789T