PROCESS FOR MANUFACTURING 2-[(3,5-DIFLUORO-3'-METHOXY-1,1'-BIPHENYL-4-YL)AMINO]NICOTINIC ACID

This invention is directed to a process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid, which comprises the steps of: a) providing 3,5-difluoro-3'-methoxybiphenyl-4-amine, b) preparing and isolating an aminium salt of the 3,5-difluoro-3'-met...

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Bibliographic Details
Main Author MARIA CARMEN BOIX BERNARDINI
Format Patent
LanguageEnglish
Portuguese
Published 28.05.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention is directed to a process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid, which comprises the steps of: a) providing 3,5-difluoro-3'-methoxybiphenyl-4-amine, b) preparing and isolating an aminium salt of the 3,5-difluoro-3'-methoxybiphenyl-4-amine, and c) further reacting the aminium salt of 3,5-difluoro-3'-methoxybiphenyl-4-amine obtained in b) to obtain 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid.
Bibliography:Application Number: PT20100765586T