CO-CRYSTALS OF TRAMADOL AND NSAIDS

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain. In a preferred embodiment, co-crystals of (-)trama...

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Main Authors HELMUT HEINRICH BUSCHMANN, JORDI BENET BUCHHOLZ, LLUIS SOLÀ CARANDELL, CARLOS RAMON PLATA SALAMAN, NICOLAS TESSON, JORDI CARLES CERÓN BERTRAN
Format Patent
LanguageEnglish
Portuguese
Published 24.11.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain. In a preferred embodiment, co-crystals of (-)tramadol-(S)-naproxen (1:2) and (+)tramadol-(R)-naproxen (1:2) are prepared.
Bibliography:Application Number: PT20090736862T