PEPTIDE CAPABLE OF EXTENDING HALF-LIFE OF PEPTIDE OF INTEREST IN PLASMA

• Main Authors: NAOMI WAKABAYASHI, SEIJI SATO
• Format: Patent
• Language: English; Portuguese
• Published: 31.03.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A peptide of the following (I) or (II). (I) a peptide represented by the formula B, A-B, B-C or A-B-C in which A, B and C each is represented by the following (1), (2) and (3) and, when it is bonded to other object peptide, it is able to extent the half-life in plasma as compared with the object peptide where the physiological activity of the object peptide is still retained. (II) a peptide comprising a reversed sequence of the peptide of (I); a sequence which is represented by A-B in (I) and A or B is reversed; a sequence which is represented by B-C in (I) and B or C is reversed; or a sequence which is represented by A-B-C in (I) and A, B, C, A and B, B and C or A and C is reserved. (1) A is a peptide comprising 1 to 14 of any amino acid(s) (2) B is a peptide represented by the formula 1: (Wk-X1-Y-Zm-Wn)-(Wo-Xp-Y-Zq-Wr)s (In the formula 1, W is a basic amino acid; X and Z are any amino acids; Y is an acidic amino acid; k is 1 or 2; 1 is an integer of 4 ‰¥ 1 ‰¥ 0; m is an integer of 2 ‰¥ m‰¥ 0; 4 ‰¥ 1 + m ‰¥ 0; n is 1 or 2 ; O is 1 or 2; p is an integer of 4 ‰¥ p ‰¥ 0; q is an integer of 2 ‰¥ q ‰¥ 0; 4 ‰¥ p + q ‰¥ 0; r is 1 or 2; and s is 0 or 1.) (3) C is a peptide comprising 2 to 14 of any amino acids.