NEW METHOD FOR OBTAINING THE CRYSTALLINE FORM V OF AGOMELATINE

Process for preparing crystalline form of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (or agomelatine) comprises dissolving a solution of agomelatine in one or two solvents miscible in all proportions, where the boiling temperature is less than 120[deg] C, and the solution is atomized in an at...

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Bibliographic Details
Main Authors GERARD COQUEREL, DAMIEN MARTINS, JULIE LINOL, PASCAL LANGLOIS
Format Patent
LanguageEnglish
Portuguese
Published 25.08.2011
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for preparing crystalline form of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (or agomelatine) comprises dissolving a solution of agomelatine in one or two solvents miscible in all proportions, where the boiling temperature is less than 120[deg] C, and the solution is atomized in an atomizer. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.
Bibliography:Application Number: PT20090290608T