CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for...

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Main Authors KEITH LEE SPENCER, DENGMING XIAO, BRIAN SAFINA, CHRISTINE CHABOT, JUN LIANG, ANNA.L. BANKA, IAN S. MITCHELL, NICHOLAS C. KALLAN, ELI. M. WALLACE, JOSEF R. BENCSIK, RUI XU, JUN LI, STEPHEN.T. SCHLACHTER, JAMES F. BLAKE
Format Patent
LanguageEnglish
Portuguese
Published 23.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Bibliography:Application Number: PT20070799329T