INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17 ALPHA -ACETOXY-11 BETA -[4-(N,N-DIMETHYL-AMINO)- PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS

A new industrial process for the synthesis of solvate-free 17α-acetoxy-11 -[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII)...

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Main Authors GYOERGY VISKY, LAJOSNE DANCSI, JANOS CSOERGEI, ENDRENE MAGYARI, CSABA MOLNAR, ZOLTAN TUBA
Format Patent
LanguageEnglish
Portuguese
Published 04.06.2013
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Summary:A new industrial process for the synthesis of solvate-free 17α-acetoxy-11 -[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
Bibliography:Application Number: PT20070733862T