SYNTHESIS OF SIALIC ACID IN PLANTS

A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-...

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Main Authors LOIC FAYE, STEPHANIE AQUIN, MARC-ANDRE D'AOUST, THOMAS PACCALET, VERONIQUE GOMORD, MURIEL BARDOR, LOUIS-PHILIPPE VEZINA, CHRISTOPHE RIHOUEY, PATRICE LEROUGE
Format Patent
LanguageEnglish
Portuguese
Published 28.09.2011
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Summary:A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
Bibliography:Application Number: PT20070710612T