AZETIDINES AS MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods...

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Main Authors JOERG BUSSENIUS, CHARLES M. BLAZEY, JEAN-CLAIRE LIMUN MANALO, JEFFRY KIMO CURTIS, NEEL KUMAR ANAND, SIMONA COSTANZO, ELENA KOLTUN, TSZE H. TSANG, OWEN JOSEPH BOWLES, ANGIE INYOUNG KIM, LARISA DUBENKO, CSABA J. PETO, ABIGAIL R. KENNEDY, NAING AAY, STEVEN CHARLES DEFINA, ANAGHA ABHIJIT JOSHI, KENNETH D. RICE
Format Patent
LanguageEnglish
Portuguese
Published 14.07.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Bibliography:Application Number: PT20060825554T