NEW CRYSTALLINE FORM V OF AGOMETALINE, THE PROCESS FOR ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Crystalline form V of agomelatine (I) is new. Crystalline form V of agomelatine ((I); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide) having powder X-ray diffraction diagram, measured using a diffractometer (copper anticathode) and expressed in terms of inter-planar distance d (8.979-3.239 A[deg]), Brag...

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Bibliographic Details
Main Authors GERARD COQUEREL, JULIE LINOL, JEAN-CLAUDE SOUVIE
Format Patent
LanguageEnglish
Portuguese
Published 25.07.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Crystalline form V of agomelatine (I) is new. Crystalline form V of agomelatine ((I); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide) having powder X-ray diffraction diagram, measured using a diffractometer (copper anticathode) and expressed in terms of inter-planar distance d (8.979-3.239 A[deg]), Bragg's angle 2 theta (9.84-27.51 degrees), intensity and relative intensity (15-100 percentage with respect to the most intense), is new. Independent claims are included for: (1) the preparation of (I); and (2) a composition comprising (I) and, inert and non-toxic carriers. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen.; Sedative; Muscular-Gen.; Immunomodulator; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen.; Contraceptive; Cytostatic. MECHANISM OF ACTION : Melatoninergic receptor agonist.
Bibliography:Application Number: PT20060291251T