CONJUGATES OF MAYTANSINOID DM1 WITH ANTIBODY TRASTUZUMAB, LINKED THROUGH A NON-CLEAVABLE LINKER, AND ITS USE IN THE TREATMENT OF TUMOURS

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is...

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Bibliographic Details
Main Authors RAVI CHARI, RITA STEEVES, HONGSHENG XIE, ROBERT LUTZ, YELENA KOVTUN
Format Patent
LanguageEnglish
Portuguese
Published 08.05.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
Bibliography:Application Number: PT20040793896T