SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE

New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disord...

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Main Authors TERESA HANSEN, PAUL A. RENHOWE, SHARADHA SUBRAMANIAN, DANIEL J. POON, CYNTHIA SHAFER, CHRISTOPHER MCBRIDE, ABRAN COSTALES, SAVITHRI RAMURTHY, JOELLE VERHAGEN, BARRY H. LEVINE
Format Patent
LanguageEnglish
Portuguese
Published 02.10.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
Bibliography:Application Number: PT20040795357T