MÉTODOS PARA REDUZIR A DESCARGA DE DOSE INDUZIDA PELO ALCOÓL EM FORMAS DE DOSAGEM ORAL DE LIBERTAÇÃO SUSTENTADA DE OPIÁCEOS

• Main Authors: NIPUN DAVAR, JAYNE HASTEDT, GEMMA CASADEVALL, LINDA HEARNEY PORS, GAYATRY SATHYAN
• Format: Patent
• Language: Portuguese
• Published: 31.05.2007
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

São descritos métodos de administração de libertação sustentada de opiáceos, incluindo mas não se limitando a hidromorfona e oxicodona, que exibem propriedades melhoradas relativamente à co-administração com álcool aquoso. Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.