2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

This invention relates to compounds of general Formula (I)and pharmaceutically acceptable salts thereof, in which R1, R1a, R2, R3, R4, and (R5)a are as defined herein, to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts thereof, and to methods of using such...

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Main Authors HE, MINGYING, KANIA, ROBERT STEVEN, MCTIGUE, MICHELE ANN, ZHOU, DAHUI, DEL BEL, MATTHEW L, AHMAD, OMAR KHALED, SCHMITT, ANNE-MARIE DECHERT, TUTTLE, JAMISON BRYCE, JALAIE, MEHRAN, GALLEGO, REBECCA ANNE, ZHOU, RU, NAIR, SAJIV KRISHNAN, JOHNSON, TED WILLIAM
Format Patent
LanguageEnglish
Polish
Published 11.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to compounds of general Formula (I)and pharmaceutically acceptable salts thereof, in which R1, R1a, R2, R3, R4, and (R5)a are as defined herein, to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable salts thereof, and to methods of using such compounds, pharmaceutically acceptable salts and compositions for the treatment of abnormal cell growth, including cancer.
Bibliography:Application Number: PL20190813943T