PROCESS FOR THE PREPARATION OF AMORPHOUS FORM OF A PLATELET AGGREGATION INHIBITOR DRUG

Preparation of amorphous form of clopidogrel hydrogen sulfate (I) involves dissolving clopidogrel base in first solvent; adding sulfuric acid or its mixture and first or second solvent to the mixture; adding resultant mixture containing clopidogrel hydrogensulfate to second solvent; and filtering, o...

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Main Authors FARKAS BELA, KORTVELYESSY GYULANE, NAGY KALMAN, BARKOCZY JOZSEF, KOTAY NAGY PETER, GREGOR TAMAS, VERECZKEYNE DONATH GYORGYI, SIMIG GYULA, SZENT-KIRALLYI ZSUZSANNA
Format Patent
LanguageEnglish
Polish
Published 15.05.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Preparation of amorphous form of clopidogrel hydrogen sulfate (I) involves dissolving clopidogrel base in first solvent; adding sulfuric acid or its mixture and first or second solvent to the mixture; adding resultant mixture containing clopidogrel hydrogensulfate to second solvent; and filtering, optionally washing and drying the precipitate. ACTIVITY : Anticoagulant; Thrombolytic. MECHANISM OF ACTION : Platelet aggregation inhibitor.
Bibliography:Application Number: PL20040378711