PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF

• Main Authors: LEVILAIN, GUILLAUME, BUCHMUELLER, ANJA, NEUBAUER, THOMAS, WITTWER, MATTHIAS BEAT, FUERSTNER, CHANTAL, WITOWSKI, NORBERT, MONDRITZKI, THOMAS, SCHIRMER, HEIKO, DROEBNER, KAROLINE, WASNAIRE, PIERRE, KRETSCHMER, AXEL, KRENZ, URSULA, POOK, ELISABETH, SCHMECK, CARSTEN, TINEL, HANNA, COLLIN-KROEPELIN, MARIE-PIERRE, LUSTIG, KLEMENS, CERNECKA, HANA, KOLKHOF, PETER, FRICKE, ROBERT
• Format: Patent
• Language: English; Polish
• Published: 21.02.2022
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.