ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF

Isoquinoline compounds of formula I for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns an isoquinoline compound thereof, for use in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal...

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Main Authors CAO, JIANGUO, MITTAPALLI, GOPI KUMAR, EASTMAN, BRIAN WALTER, KC, SUNIL KUMAR, MAK, CHI CHING, BOLLU, VENKATAIAH, CHIRUTA, CHANDRAMOULI
Format Patent
LanguageEnglish
Polish
Published 02.11.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Isoquinoline compounds of formula I for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns an isoquinoline compound thereof, for use in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
Bibliography:Application Number: PL20170790416T