INHIBITORS OF EZH2

The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.

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Bibliographic Details
Main Authors RODRIGUEZ, MICHAEL JOHN, YU, KUO-LONG, NGUYEN, ANH-QUAN HANNAH, DOMINGUEZ, ESTEBAN, MADER, MARY MARGARET, GUO, DEQI, RICHETT, MICHAEL ENRICO, DEL PRADO, MIRIAM FILADELFA, YIP, YVONNE YEE MAI
Format Patent
LanguageEnglish
Polish
Published 18.05.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.
Bibliography:Application Number: PL20160757513T