ANTIBODY EPITOPE

It has been demonstrated that certain compounds bind to TNT and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compoun...

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Bibliographic Details
Main Authors O'CONNELL, JAMES PHILIP, ARAKAKI, TRACY LYNN, LIGHTWOOD, DANIEL JOHN, PORTER, JOHN ROBERT, LAWSON, ALASTAIR, WOOTTON, REBECCA JAYNE
Format Patent
LanguageEnglish
Polish
Published 28.03.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:It has been demonstrated that certain compounds bind to TNT and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
Bibliography:Application Number: PL20150784370T