ENOLASE INHIBITORS AND METHODS OF TREATMENT THEREWITH

Provided herein are compounds of the formula:wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes....

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Bibliographic Details
Main Authors BORNMANN, WILLIAM G, PRASAD, BASVOJU A BHANU, SATANI, NIKUNI, CZAKO, BARBARA, MULLER, FLORIAN, DEPINHO, RONALD A, MAXWELL, DAVID S, LIN, YU-HSI, SUN, DUOLI, PISANESCHI, FEDERICA, PENG, ZHENGHONG, DIFRANSESCO, M. EMILIA
Format Patent
LanguageEnglish
Polish
Published 23.05.2022
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the formula:wherein the variables R1, R2, R3, R4, X1, X2, Y1, and A1 are as defined herein. Such compounds may be used, for example, for the inhibition of enolase enzymes, including preferential inhibition of one isoenzyme of over one or more of the other isoenzymes. Methods of treatment using these compounds, as well as pharmaceutical compositions thereof, are also provided.
Bibliography:Application Number: PL20160712592T