DERIVATIVE OF ACETAMIDE, METHOD OF OBTAINING SAME AND PHARMACEUTIC COMPOSITION CONTAINING IT

Acetamide derivatives represented by general formula (I) and physiologically acceptable acid-addition salts thereof, wherein X represents -O- or -NR4; R1 represents H, lower alkyl, lower alkenyl or cycloalkyl(lower)alkyl; R2 represents lower alkyl, cycloalkyl, optionally substituted phenyl, etc.; R3...

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Bibliographic Details
Main Authors HINO KATSUHIKO, MURATA TERUYA, ITOH MARI, OKA MAKOTO, FURUKAWA KIYOSHI
Format Patent
LanguageEnglish
Published 16.02.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Acetamide derivatives represented by general formula (I) and physiologically acceptable acid-addition salts thereof, wherein X represents -O- or -NR4; R1 represents H, lower alkyl, lower alkenyl or cycloalkyl(lower)alkyl; R2 represents lower alkyl, cycloalkyl, optionally substituted phenyl, etc.; R3 represents H, lower alkyl or hydroxy(lower)alkyl; R4 represents H, lower alkyl, etc.; R5 represents H, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, etc.; R6 represents H, lower alkyl, CF3 or optionally substituted phenyl, or R5 and R6 together form -(CH2)n-; R7 represents H, halogeno, lower alkyl, lower alkoxy, CF3, OH, NH2, etc.; and R8 represents H, halogeno, lower alkyl or lower alkoxy. The compounds act selectively on the peripheral BZ omega 3 receptor and exhibit excellent pharmocological effects, which makes them useful as a remedy and preventive for central diseases, for example, diseases associated with anxiety, depression and epilepsy, etc.
Bibliography:Application Number: PL19960322819