CRYSTALLINE FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE

The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is su...

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Main Authors XU, JEAN, LI, YING, MUSLEHIDDINOGLU, JALE, BEAUCHAMPS, MARIE GEORGES, YONG, KELVIN HIN-YEONG, HUANG, LIANFENG, FERRETTI, ANTONIO CHRISTIAN, KOTHARE, MOHIT ATUL, BOERSEN, NATHAN ANDREW, NAGY, MARK A, HILGRAF, ROBERT, ZOU, NANFEI, MAN, HON-WAH, ZOU, DAOZHONG
Format Patent
LanguageEnglish
Polish
Published 08.03.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a method of preparing compound of formula (iv),by contacting the compound of formula (iii) with R1NH2 in the presence of a base or a Lewis acid, in a solvent as defined herewith. The invention further provides a compound of formula (iii),and tautomers thereof, wherein R2 is substituted or unsubstituted C1-8 alkyl, or substituted saturated cycloalkyl as defined herein.
Bibliography:Application Number: PL20150743503T