NOVEL LINEAR PEPTIDES AND METHOD OF OBTAINING THEM AS WELL AS PHARMACEUTIC PREPARATION AND METHOD OF OBTAINING SAME

Linear peptides of the formula I X-A-Cys(R )-B-Z I, wherein A, B, R , X and Z have the meaning indicated in Claim 1, are effective inhibitors of binding of the blood platelet integrin GP IIbIIIa (aIIbss3) to natural ligands and are suitable, inter alia, for the prophylaxis and the treatment of disor...

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Bibliographic Details
Main Authors FELDING BRUNHILDE, JONCZYK ALFRED, RIPPMANN FRIEDRICH, DIEFENBACH BEATE
Format Patent
LanguageEnglish
Published 02.05.1995
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Linear peptides of the formula I X-A-Cys(R )-B-Z I, wherein A, B, R , X and Z have the meaning indicated in Claim 1, are effective inhibitors of binding of the blood platelet integrin GP IIbIIIa (aIIbss3) to natural ligands and are suitable, inter alia, for the prophylaxis and the treatment of disorders of the circulation, in thrombosis, cardiac infarct, coronary heart disorders, arterio- and atherosclerosis, tumours, osteolytic disorders, and assist in wound healing processes.
Bibliography:Application Number: PL19940305632