CARBAZOLONE DERIVATIVES AND METHOD OF OBTAINING SAMES

The invention relates to carbazolone derivatives of the formula wherein A stands for a group of formula -CH2-R (V), wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; B represents a group of formula wherein R1 means hydrogen or a methyl or ethyl group; or A and B together form a group of...

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Bibliographic Details
Main Authors CSEHI ATTILA, HEGEDUS BELA, MERSICH NEE DONAT EVA, SZABO NEE KOMLOSI GYORGYI, HORVATH NEE SZIKI ERIKA, BOD PETER, TRISCHLER FERENC, FEKECS EVA, HARSANYI KALMAN
Format Patent
LanguageEnglish
Published 18.04.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to carbazolone derivatives of the formula wherein A stands for a group of formula -CH2-R (V), wherein R means a hydroxyl or 2-methyl-1H-imidazol-1-yl group; B represents a group of formula wherein R1 means hydrogen or a methyl or ethyl group; or A and B together form a group of formula wherein R2 means a methyl or ethyl group; or A and B together form a group of formula The above compounds are useful intermediates in the synthesis of ondansetron of formula chemically 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-c arbazol-4-one. The invention further relates to a novel process for the preparation of compounds of the formula (I), wherein A and B are the same as in formula (I).
Bibliography:Application Number: PL19930300685