6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to p...

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Main Authors MACDONALD, GREGOR JAMES, CID-NÚÑEZ, JOSÉ MARIA, DELGADO-GONZÁLEZ, ÓSCAR, GARCÍA-MOLINA, ARÁNZAZU, MEGENS, ANTONIUS ADRIANUS HENDRIKUS PETRUS, DECORTE, ANNELIES MARIE ANTONIUS, ALONSO-DE DIEGO, SERGIO-ALVAR, TRABANCO-SUÁREZ, ANDRÉS AVELINO, ANDRÉS-GIL, JOSÉ IGNACIO, VAN GOOL, MICHIEL LUC MARIA
Format Patent
LanguageEnglish
Polish
Published 31.10.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
Bibliography:Application Number: PL20140727824T