Human monoclonal antibodies to activin receptor-like kinase-1 (ALK-1)

• Main Authors: KELLERMANN, SIRID-AIMEE, WICKMAN, GRANT RAYMOND, AMUNDSON, KARIN KRISTINA, HU-LOWE, DANA DAN, ZHANG, JINGCHUAN, BELOUSKI, SHELLEY SIMS, JIANG, XIN, KARLICEK, SHANNON MARIE, WANG, JIANYING, THOMSON, JAMES ARTHUR, NORTH, MICHAEL AIDAN, BEDIAN, VAHE
• Format: Patent
• Language: English; Polish
• Published: 31.12.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The disclosure also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The disclosure also relates to non-human transgenic animals or plants comprising nucleic acid molecules of the present disclosure.