Method of producing polymer nanoparticles chelating radioactive isotopes for use in diagnostics and treatment

The method for preparation of radiolabelled radioisotope-chelating polymer nanoparticles, optionally with their surface modified with specific molecules targeting particular type of cancer cells and/or cancer extracellular space, allowing for their storage, the method comprising addition of hydropho...

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Bibliographic Details
Main Authors JANCZEWSKA, MAGDALENA, SZKOP, MICHAŁ, DUSZAK, JOLANTA, ZUK, MICHAŁ TOMASZ, CIACH, TOMASZ
Format Patent
LanguageEnglish
Polish
Published 06.06.2022
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:The method for preparation of radiolabelled radioisotope-chelating polymer nanoparticles, optionally with their surface modified with specific molecules targeting particular type of cancer cells and/or cancer extracellular space, allowing for their storage, the method comprising addition of hydrophobic diamines, wherein a chelator molecule is attached to a free amine group of diamine via an amide bond. Radiolabelled polymeric nanoparticles chelating radioisotopes prepared in the claimed method, optionally having their surface modified with specific molecules targeting to specific types of cancer cells, and the use thereof in diagnostics and therapy.
Bibliography:Application Number: PL20190429333