MONOCLONAL ANTIBODIES AGAINST THE RGM A PROTEIN AND USES THEREOF

The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for de...

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Bibliographic Details
Main Authors HSIEH, CHUNG-MING, BARDWELL, PHILLIP D, BARLOW, EVE H, LEDDY, MARY R, MÜLLER, BERNHARD K, SCHMIDT, MARTIN
Format Patent
LanguageEnglish
Polish
Published 29.01.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The subject invention relates to monoclonal antibodies which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or antigen binding fragments thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.
Bibliography:Application Number: PL20090715176T