Composition containing drug conjugate including the calicheamicin derivatives and the antibody, and the pharmaceutical composition containing it

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the...

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Main Authors KUNZ ARTHUR, MERCHANT NISHITH, RUBINO JOSEPH THOMAS, SIMPSON JOHN MCLEAN, POPPLEWELL ANDREW GEORGE, JAIN NEERA, ROBBINS PAUL DAVID, MORAN JUSTIN KEITH, VIDUNAS EUGENE JOSEPH, RUPPEN MARK EDWARD, DAMLE NITIN KRISHNAJI, DIJOSEPH JOHN FRANCIS
Format Patent
LanguageEnglish
Polish
Published 30.11.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with dicreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Bibliography:Application Number: PL20030410219