POLYMORPHS OF A 1-PYRROLE DERIVATIVE, INTERMEDIATE FOR THE PREPARATION OF ATORVASTATIN

The invention relates to new crystalline forms I and II of (4R-cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluoro-phenyl)-5-(1- methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of the Formula (I) and a process for the preparation thereof. The new po...

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Main Authors BARTHA FERENC, SZENT KIRÁLLYI ZSUZSA, BARKÓCZY JÓZSEF, KÓTAY NAGY PÉTER, NAGY KÁLMÁN, SIMIG GYULA, GREFF ZOLTÁN, VERECZKEYNÉ DONÁTH GYORGYI
Format Patent
LanguageEnglish
Polish
Published 30.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to new crystalline forms I and II of (4R-cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluoro-phenyl)-5-(1- methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of the Formula (I) and a process for the preparation thereof. The new polymorphs of the present invention are useful pharmaceutical intermediates which can be used in the preparation of the hydroxymethyl-glutaryl coenzyme (HMG-COA) reducing enzyme inhibitor having the INN (International Non-proprietory Name) atorvastatin
Bibliography:Application Number: PL20020369227