INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv...

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Main Authors JOHNSON MICHAEL DAVID, LUU HIEP THE, PALMER CYNTHIA LOUISE, BORCHARDT ALLEN J, BRAGANZA JOHN F, KANIA ROBERT STEVEN, VARNEY MICHAEL DAVID, BENDER STEVEN LEE, TENG MIN, HUA YE, THOMAS CHRISTINE, JOHNSON THEODORE OTTO JR, REICH SIEGFRIED HEINZ, CRIPPS STEPHAN JAMES, WALLACE MICHAEL BRENNAN, COLLINS MICHAEL RAYMOND, TEMPCZYK-RUSSELL ANNA MARIA
Format Patent
LanguageEnglish
Polish
Published 31.08.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Bibliography:Application Number: PL20000355757