PROCESS FOR PREPARING FLUCONAZOLE AND ITS CRYSTAL MODIFICATIONS

A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1...

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Main Authors FARKAS JEN NE, HEGED S ISTVAN, WERKNE PAPP EVA, DEUTSCHNE JUHASZ IDA, KREIDL JANOS, SZANTAY CSABA, CZIBULA LASZLO, NAGYNE BAGDY JUDIT, PILLER AGNES
Format Patent
LanguageEnglish
Polish
Published 31.05.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) wherein R2 is hydrogen, or a C1 to C10 alkyl or phenyl group, R3 and R4 independently of each other are a C1 to C10 alkyl or phenyl group in an aqueous solution, preferably at a pH below 3 or above 8.
Bibliography:Application Number: PL20010363756