2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES ANT THEIR ANTIINFLAMMATORY ACTIVITY

• Main Authors: COOYMANS LUDWIG PAUL, DE BRABANDER MARC J, VAN WAUWE JEAN PIERRE FRANS, DIELS GASTON STANISLAS MARCELLA, LOVE CHRISTOPHER JOHN, SIBLEY ANTHONY WILLIAM, MOSES ROGER CLIVE, VANDERMAESEN NELE, GONCHARENKO MYKHAYLO, NOULA CATERINA
• Format: Patent
• Language: English; Polish
• Published: 31.01.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C1-6alkyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(C1-6alkyl)amino, aminocarbonyl, mono- or di(C1-6alkyl)aminocarbonyl, C1-6alkyloxycarbonyl or C1-6alkyloxy; polyhaloC1-4alkyl; C1-4alkyloxy; cyano; amino; aminocarbonyl; mono- or di(C1-6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; H2N-S(-O)2-; mono- or di(C1-6alkyl)amino-S(-O)2; -C(-N-Rx)NRyRz; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-alpha and/or IL-12.