Method of obtaining derivatives of spiro[cis-4-(beta-hydroetoxy) cyclohexane-[3H]indol]-one

The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2...

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Bibliographic Details
Main Authors GONCZI CSABA, HERMECZ ISTVAN, HAJDU FELIX, HEJA GERGELY, NAGY LAJOS, SIMON KALMAN, KIS LASZLO, SZVOBODA GYORGYNE, SZOMOR TIBORNE, HALASZ JUDIT, CSIKOS EVA, SANTANE CSUTOR ANDREA
Format Patent
LanguageEnglish
Polish
Published 30.06.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2''[1''H]-one derivative of general formula (II), wherein R1 and R2 are as defined herein, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.
Bibliography:Application Number: PL20000352475