Novel antiarrhytmic compounds

The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1)whereinR1 and R2, independently from each other, mean hydrogen,...

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Main Authors DRUGA ALICE, MATYUS PETER, RETTEGI TIVADAR, VARRO ANDRAS, BERZSENYI PAL, PATFALUSI MARTA, SIMAY ANTAL, BARLOCCO DANIELLA, PAPP GYULA, VARGA ILDIKO, CIGNARELLA GIORGIO, MORAVCSIK IMRE
Format Patent
LanguageEnglish
Polish
Published 31.01.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to novel, antiarrhythmically active phenoxyalkylamine derivatives possessing a double point of attack. More particularly, the present invention relates to new phenoxyalkylamine derivatives of the formula (1)whereinR1 and R2, independently from each other, mean hydrogen, halogen or C1-4 alkyl group;R3, R4 and R5, independently from each other, stand for hydrogen or C1-4 alkyl group;R6 represents hydrogen, C1-4 alkyl or benzyl group;R7 means nitro group or amino group optionally monosubstituted by C1-4 alkyl, benzoyl, C1-4 alkylcarbonyl, C1-4 alkylsulfonyl, C1-4 alkylcarbamoyl or C1-4 alkylthiocarbamoyl group;both n and m are 0 or 1,with the proviso that R2 is different from hydrogen, when R1 is hydrogen,as well as stereoisomers or mixtures of stereoisomers thereof, acid addition salts thereof and hydrates, prodrugs and metabolites of all these compounds.
Bibliography:Application Number: PL19980341107