CYCLOPEPTOLYDES

• Main Authors: DREYFUSS MICHAEL, OBERHAUSER BERNDT, FOSTER CAROLYN ANN, FEHR THEODOR, GEYL DIETER
• Format: Patent
• Language: English; Polish
• Published: 30.09.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

A cyclopeptolide of formula cyclo(A-B-R1Leu-Leu-C-X-Y) (I) in the free, salt or ester form is new. In (I) A = a glycolic acid residue opt. ~a-substd. by H, Me, Et, propyl or vinyl, opt. substd. by halo, alkoxy, opt. protected OH or NH2, CSNH2, COOR2, vinyl, -C?=CH or thiazole, and opt. substd. by alkyl, halo, cycloalkyl, opt. substd. thiazole, COOR2 or -C?=CH; R2 = H or lower alkyl ; B = an ~a-amino-~c-methyl-substd. octanoic acid residue; R1 = H or Me; C = a tryptophan or N-methyl tryptophan residue of formula (II); R3 = H, alkoxy, alkyl or benzyl; R4 = H or halo; R5 = H or methyl; the dotted line is an opt. double bond; Y = an ~a-amino or N-methyl-~a-amino substd. (2-10C) carboxylic acid residue; X = an ~a-amino substd. (2-14C) carboxylic acid residue. Also new is the fungal strain F/94-499709 deposited as DSM 10275 or a mutant or derivative thereof.