METHOD OF OBTAINING AMINOMETHYL-2-FURYL/METHYLOTHIO]-1-ETHYLAMINE}-3 NITRO-4-NITROMETHYLENE-2-AZETINE

The invention relates to the novel compound of formula (I), chemically 1-{2-[(5-N,N-dimethylaminomethyl-2-furyl)-methylthio]ethyl}-2-{2-[(5-N ,N-dimethylaminomethyl-2-furyl)-methylthio]-1-ethylamino} -3-nitro-4-nitromethylene-2-azetine, which is a useful key intermediate in the synthesis of 1-{2-[(5...

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Main Authors CZEH ZOLTANNE, HAVASI GABOR, LOSONCZI BELA, GODO LASZLO, KALVIN PETER, HERMANN LASZLO, STEFKO BELA, MEGYERI GABOR, BENCZIK TAMAS, STEFAN LASZLO, JESZENSZKI ANDOR
Format Patent
LanguageEnglish
Published 31.05.1995
Edition6
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to the novel compound of formula (I), chemically 1-{2-[(5-N,N-dimethylaminomethyl-2-furyl)-methylthio]ethyl}-2-{2-[(5-N ,N-dimethylaminomethyl-2-furyl)-methylthio]-1-ethylamino} -3-nitro-4-nitromethylene-2-azetine, which is a useful key intermediate in the synthesis of 1-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethyl}-amino-1-methyla mino-2-nitroethylene (generic name: ranitidine), a known H-2 receptor antagonist. The invention further relates to a process for the preparation of the compound of formula (I), which can be carried out in one simple process step on industrial scale, too. The compound of formula (I) can easily be transformed to ranitidine in one simple step.
Bibliography:Application Number: PL19910292326