PHENYL-PYRROLIDINOETHOXYENZOYL-(1,2-DIHYDRO-NAPTHALENE OR NAPHTHALENE)AND DERIVATIVES

• Main Authors: SUAREZ JULIO, JONES CHARLES D
• Format: Patent
• Language: English
• Published: 24.09.1981
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Aroylphenylnaphthalenes of the formula I in which X is -CH2-CH2- or -CH=CH-, R is hydrogen or C1-C5-alkoxy, R1 is hydrogen or C1-C5-alkoxy, and the substituents R2 and R3 form, together with the nitrogen atom to which they are bonded, a pyrrolidino group, and the pharmaceutically acceptable non-toxic acid addition salts thereof are obtained by reacting a naphthalene derivative with a chloro-2-aminoethane, and converting resulting compounds of the formula I where appropriate into the pharmaceutically acceptable non-toxic acid addition salts. The compounds of the formula (I) which can be prepared according to the invention are, as a rule, valuable medicines. They are normally distinguished particularly by a fertility-inhibiting action and are therefore suitable in particular as orally active fertility-inhibiting agents in birds and mammals. The compounds of the formula (I) which can be prepared according to the invention may therefore be suitable for controlling the animal population and as contraceptives for life forms. These compounds can furthermore also be used, for example, to control animal pests.