PYRAZOLES AS MODULATORS OF HEMOGLOBIN

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically...

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Main Authors HEPWORTH, David, PARIKH, Mihir Dineshkumar, ROBINSON, JR., Ralph Pelton, CHOI, Chulho, JONES, Lyn Howard, PIOTROWSKI, David Walter, NARAYANAN, Arjun Venkat, DOW, Robert Lee, JASTI, Jayasankar, GOPALSAMY, Ariamala, CABRAL, Shawn, YAYLA, Hatice Gizem, CASIMIRO-GARCIA, Agustin, ROBERTS, Lee Richard, FADEYI, Olugbeminiyi Omezia, CHEN, Ming Zhu
Format Patent
LanguageEnglish
Published 06.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).
Bibliography:Application Number: PH20211551035