LYMPHOCYTES EXPRESSING HETEROLOGOUS TARGETING CONSTRUCTS
The present invention provides engineered lymphocytes (e.g., ?d T cells, NK cells, NK-like T cells, engineered innate lymphoid cells, or MAIT cells) comprising a heterologous targeting construct lacking an intracellular signaling domain capable of activating the lymphocyte on which the construct is...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
07.06.2021
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides engineered lymphocytes (e.g., ?d T cells, NK cells, NK-like T cells, engineered innate lymphoid cells, or MAIT cells) comprising a heterologous targeting construct lacking an intracellular signaling domain capable of activating the lymphocyte on which the construct is expressed. Further provided are compositions of engineered lymphocytes (e.g., ?d T cells) and methods of using the engineered lymphocytes (e.g., ?d T cells, e.g., a part of an adoptive T cell therapy). |
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Bibliography: | Application Number: PH20201551538 |