BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS

Compounds of general formula (la), compounds of general formula (la'), compounds of general formula (lb), compounds of general formula (lb'), compounds of general formula (I), compounds of general formula (?'), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R...

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Main Authors CUMMING, Jared, N, TROTTER, Benjamin Wesley, CASH, Brandon, D, LU, Min, TYAGARAJAN, Sriram, OTTE, Ryan, D, CHANG, Wonsuk, LIM, Jongwon, HENDERSON, Timothy, J, LIANG, Rui, LARSEN, Matthew, A, HAIDLE, Andrew, M, JEWELL, James, P, ALTMAN, Michael, D, SIU, Tony
Format Patent
LanguageEnglish
Published 02.12.2019
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Summary:Compounds of general formula (la), compounds of general formula (la'), compounds of general formula (lb), compounds of general formula (lb'), compounds of general formula (I), compounds of general formula (?'), and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, R6, R8, R9, X1, X2, and X3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds of the disclosure.
Bibliography:Application Number: PH20191500712