FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME

The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment...

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Main Authors KULMAN, John, LIU, Tongyao, STEMMER, Willem, P, WANG, Chia-wei, VARFAJ, Fatbardha, CHANG, Pei-yun, JIANG, Haiyan, GEETHING, Nathan, WANG, Deping, DING, Sheng, SCHELLENBERGER, Volker, PETERS, Robert, SILVERMAN, Joshua, MEI, Baisong, SPINK, Benjamin, TOBY, Garabet, G
Format Patent
LanguageEnglish
Published 15.03.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor Vlll-related diseases, disorders, and conditions.
Bibliography:Application Number: PH20191500694