EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO

The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the spec...

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Bibliographic Details
Main Authors TRAN, Chinh, PACKARD, Garrick, Kenneth, REICH, Siegfried, H, NILEWSKI, Christian, XIANG, Alan, Xin, ERNST, Justin, T, MICHELS, Theodore, SPRENGELER, Paul, A
Format Patent
LanguageEnglish
Published 21.01.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For Formula (I) compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula (I) compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
Bibliography:Application Number: PH20181501073