EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT ?d T CELLS AND USES OF THESE CELLS

This invention relates to the expansion of non-haematopoietic tissue-resident ?d T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or...

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Bibliographic Details
Main Authors NUSSBAUMER, Oliver, WOOLF, Richard, HAYDAY, Adrian
Format Patent
LanguageEnglish
Published 05.11.2018
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This invention relates to the expansion of non-haematopoietic tissue-resident ?d T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident ?d T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident ?d T cells and uses thereof.
Bibliography:Application Number: PH20181500926