BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS

The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof. The compounds are inhibitors of ERK 1/2 kinases and will be useful in the treatment of ERKl/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the...

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Main Authors DAY, James Edward Harvey, ONIONS, Stuart Thomas, GRIFFITHS-JONES, Charlotte Mary, COUSIN, David, MURRAY, Christopher William, WOOLFORD, Alison Jo-Anne, SHANNON, Jonathan Martin, BUCK, Ildiko Maria, HEIGHTMAN, Thomas Daniel, NORTON, David, BERDINI, Valerio, O'REILLY, Marc, HOWARD, Steven, COOKE, Michael Liam, WATTS, John Paul
Format Patent
LanguageEnglish
Published 01.10.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof. The compounds are inhibitors of ERK 1/2 kinases and will be useful in the treatment of ERKl/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the treatment of cancer.
Bibliography:Application Number: PH20181500792