BETA HAIRPIN PEPTIDES HAVING ANTIVIRAL PROPERTIES AGAINST DENGUE VIRUS

The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these...

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Main Authors MARQUEZ PERERA, Gabriel, Jes£s, HUERTA GALINDO, Vivian, REYES ACOSTA, Osvaldo, SARRIA NU¥EZ, M¢nica, MARTIN DUNN, Alejandro, Miguel, CHINEA SANTIAGO, Glay, GARATEIX SUAREZ, Rocio, YERO DIAZ, Alexis, FALCON CAMA, Viviana, GONZALEZ BLANCO, Sonia, VAZQUEZ CASTILLO, Mariela, PUPO GOMEZ, Dianne, GUIROLA CRUZ, Osmany, GONZALEZ LOPEZ, Luis, Javier, GARAY PREZ, Hilda, Elisa, ALVAREZ PREZ, Karen
Format Patent
LanguageEnglish
Published 19.12.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused 10 infections. Likewise, the invention disclosed a method for treating infections caused by this virus.
Bibliography:Application Number: PH20161501715