NOVEL POLYSACCHARIDE AND USES THEREOF

Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier...

Full description

Saved in:
Bibliographic Details
Main Authors KOWARIK, Michael, T, HŽUPTLE, Micha, A, WETTER, Michael, L, KEMMLER, Stefan, J, MALLY, Manuela, GAMBILLARA, Veronica
Format Patent
LanguageEnglish
Published 03.10.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce 025B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, comprising O25B and/or bioconjugates comprising O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further comprise one or more additional bioconjugates.
Bibliography:Application Number: PH20161501671