HIGH AFFINITY AND AGGREGATIVELY STABLE ANTIBODIES ON THE BASIS OF VAIRABLE DOMAIN VL AND A DERIVATIVE VHH

• Main Authors: EKIMOVA, VICTORIA MIKHAILOVNA, ULITIN, ANDREY BORISOVICH, EVDOKIMOV, STANISLAV RUDOLFOVICH, GONCHAROVA, OLGA VLADIMIROVNA, NEMANKIN, TIMOFEY ALEKSANDROVICH, CHERNYH, YULIA SERGEEVNA, IVANOV, ROMAN ALEXEEVICH, MOROZOV, DMITRIY VALENTINOVICH, SOFRONOVA, EKATERINA VLADIMIROVNA, KORZHAVIN, DMITRIY VALERIEVICH, USTYUGOV, YAKOV YUREVICH, SOLOVIEV, VALERIY VLADIMIROVICH, CHERNOVSKAYA, TATYANA VENIAMINOVNA
• Format: Patent
• Language: English
• Published: 15.08.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

What are proposed are: monoclonal antibodies of the type IgG comprising variable domains in the form of a combination of a derivative VHH with a variable domain of a light chain VL. The antibodies mentioned may comprise amino acid substitutions in positions 44 and/or 45 (according to the Kabat numbering scheme) or combinations thereof. The antibodies described have increased affinity and improved aggregation stability.